Assessing Sensitivity and Specificity of Surveillance Case Definitions for Zika Virus Disease

Researchers evaluated the performance of 5 Zika case definitions recommended by the Council of State and Territorial Epidemiologists, World Health Organization, Pan American Health Organization, European Centers for Disease Control, and the Singapore Ministry of Health. They utilized these definitions for Zika virus disease surveillance in a human cohort of 359 adult patients with suspected Zika virus disease during an outbreak in Singapore, August 26–September 5, 2016. Because laboratory tests are largely inaccessible, use of case definitions that include rash as a required clinical feature are useful in identifying this disease.
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